Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a part of endothelial dysfunction has been proposed, which may contribute to abnormal vessel reactivity. However, testosterone in physiologic doses might even be helpful in patients with angina , have larger ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood move in males with established coronary artery illness .
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We report a case of an acute ST-segment elevation myocardial infarction in a affected person with conventional cardiac threat elements utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient additionally had polycythemia, likely secondary to high-dose testosterone. The affected person underwent profitable percutaneous intervention of the proper coronary artery. Physicians and sufferers ought to pay attention to the medical consequences of anabolic steroid abuse.
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Unfortunately, the information on using excessive dose anabolic steroids in humans are mainly supplied as case stories or small studies that lack sufficient management teams. In addition, the info available within the literature doesn’t account for the steroid sort or dose, as neither could additionally be identified. Patients additionally could also be taking concomitant stimulants, such as ephedra, which may confound knowledge and the potential for adverse occasions. It is most likely going that the frequency of cardiac events is underreported within the medical literature. Supraphysiologic doses of anabolic-androgenic steroids , which embrace greater than 30 pure and synthetic derivatives of testosterone, could trigger a wide spectrum of medical sequalae.
